Dissociable roles of dopamine within the core and medial shell of the nucleus accumbens in memory for objects and place.

Citation

Nelson, A. J. D., Thur, K. E., Marsden, C. A., & Cassaday, H. J. (2010). Dissociable roles of dopamine within the core and medial shell of the nucleus accumbens in memory for objects and place. Behavioral Neuroscience, 124(6), 789-799.

http://dx.doi.org/10.1037/a0021114

Abstract

There is increasing focus on the role of the nucleus accumbens (NAc) in learning and memory, but there is little consensus as to how the core and medial shell subregions of the NAc contribute to these processes. In the current experiments, we used spontaneous object recognition to test rats with 6-hydroxydopamine lesions targeted at the core or medial shell of the NAc on a familiarity discrimination task and a location discrimination task. In the object recognition variant, control animals were able to discriminate the novel object at both 24-hr and 5-min delay. However, in the lesion groups, performance was systematically related to dopamine (DA) levels in the core but not the shell. In the location recognition task, sham-operated animals readily detected the object displacement at test. In the lesion groups, performance impairment was systematically related to DA levels in the shell but not the core. These results suggest that dopamine function within distinct subregions of the NAc plays dissociable roles in the modulation of memory for objects and place. (PsycINFO Database Record (c) 2016 APA, all rights reserved)

Unique Identifier

2010-24688-006

Title

Dissociable roles of dopamine within the core and medial shell of the nucleus accumbens in memory for objects and place.

Publication Date

Dec 2010

Publication History

Accepted: Jul 23, 2010

Revised: Jun 23, 2010

First Submitted: Mar 22, 2010

Language

English

Author Identifier

Nelson, Andrew J. D.; Thur, Karen E.; Marsden, Charles A.; Cassaday, Helen J.

Author Identifier

Nelson, Andrew J. D. http://orcid.org/0000-0002-5171-413X

Cassaday, Helen J. http://orcid.org/0000-0002-9227-373X

Email

Nelson, Andrew J. D.: andrew.nelson@nottingham.ac.uk

Correspondence Address

Nelson, Andrew J. D.: School of Psychology, University of Nottingham, University Park, Nottingham, United Kingdom, NG7 2RD

Affiliation

Nelson, Andrew J. D.: School of Psychology, University of Nottingham, Nottingham, United Kingdom

Thur, Karen E.: School of Psychology, University of Nottingham, Nottingham, United Kingdom

Marsden, Charles A.: School of Biomedical Sciences, University of Nottingham, Nottingham, United Kingdom

Cassaday, Helen J.: School of Psychology, University of Nottingham, Nottingham, United Kingdom

Source

Behavioral Neuroscience, Vol 124(6), Dec 2010, 789-799.

NLM Title Abbreviation

Behav Neurosci

ISSN

1939-0084(Electronic); 0735-7044(Print)

PMID

21133535

Publisher

US: American Psychological Association

Format Covered

Electronic

Publication Type

Journal; Peer Reviewed Journal

Document Type

Journal Article

Digital Object Identifier

http://dx.doi.org/10.1037/a0021114

Keywords

dopamine; nucleus accumbens; object memory; place memory; rat; medial shell region; core region; brain lesions

Index Terms

*Dopamine; *Memory; *Nucleus Accumbens; *Object Recognition; *Brain Lesions (Experimental); Animal Learning; Rats

PsycINFO Classification

2520 Neuropsychology & Neurology

MeSH

Analysis of Variance; Animals; Dopamine; Male; Mental Recall; Neurons; Nucleus Accumbens; Organ Specificity; Oxidopamine; Rats; Rats, Wistar; Recognition (Psychology)

Population Group

Animal; Male

Copyright

Holder: American Psychological Association

Year: 2010

Methodology

Empirical Study; Quantitative Study

Grant Sponsorship

Sponsor: Wellcome Trust
Recipient: No recipient indicated
Grant Number: 082940

Release Date

20101206 (PsycINFO); 20101206 (PsycARTICLES)

References

Number of Citations: 131, Number of Citations Displayed: 131

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